The Chief Minister of Sindh (CM) is elected by the Provincial Assembly of Sindh to serve as the head of the provincial government in Sindh, Pakistan. The current Chief Minister is Qaim Ali Shah, who belongs to Pakistan Peoples Party. He was elected as 23rd CM on April 7, 2008.
| Name of Chief Minister | Entered Office | Left Office | Political Party/Notes |
|---|---|---|---|
| Ghulam Hussain Hidayat Ullah (1st time) | April 28, 1937 | March 23, 1938 | Muslim People's Party |
| Allah Bux Soomro (1st time) | March 23, 1938 | April 18, 1940 | Ittehad Party |
| Mir Bandeh Ali Khan Talpur | April 18, 1940 | March 7, 1941 | Muslim League |
| Allah Bux Soomro (2nd time) | March 7, 1941 | October 14, 1942 | Ittehad Party |
| Ghulam Hussain Hidayat Ullah (2nd time) | October 14, 1942 | August 14, 1947 | Muslim People's Party |
| Muhammad Ayub Khuhro (1st time) | August 16, 1947 | April 28, 1948 | Muslim League |
| Pir Ilahi Bux | May 3, 1948 | February 4, 1949 | Muslim League |
| Yusuf Haroon | February 18, 1949 | May 7, 1950 | Muslim League |
| Qazi Fazlullah Ubaidullah | May 8, 1950 | March 24, 1951 | Muslim League |
| Muhammad Ayub Khuhro (2nd time) | March 25, 1951 | December 29, 1951 | Muslim League |
| Governor's rule | December 29, 1951 | May 22, 1953 | |
| Pirzada Abdul Sattar | May 22, 1953 | November 8, 1954 | Muslim League |
| Muhammad Ayub Khuhro (3rd time) | November 9, 1954 | October 13, 1955 | Muslim League |
| Post abolished | October 13, 1955 | June 30, 1970 | Part of West Pakistan province |
| Martial law | July 1, 1970 | May 1, 1972 | |
| Mumtaz Bhutto (1st time) | May 1, 1972 | December 20, 1973 | Pakistan Peoples Party |
| Ghulam Mustafa Jatoi | December 25, 1973 | July 5, 1977 | Pakistan Peoples Party |
| Martial law | July 5, 1977 | April 6, 1985 | |
| Ghous Ali Shah | April 6, 1985 | April 6, 1988 | Pakistan Muslim League |
| Akhtar Ali Ghulam Qazi (1st time) | April 11, 1988 | June 24, 1988 | Islami Jamhoori Ittehad |
| Governor's rule | June 24, 1988 | August 31, 1988 | |
| Akhtar Ali Ghulam Qazi (2nd time; caretaker) | August 31, 1988 | December 2, 1988 | Islami Jamhoori Ittehad |
| Qaim Ali Shah | December 2, 1988 | February 25, 1990 | Pakistan Peoples Party |
| Aftab Shaban Mirani | February 25, 1990 | August 6, 1990 | Pakistan Peoples Party |
| Jam Sadiq Ali (acting till November 5, 1990) | August 6, 1990 | March 5, 1992 | Independent |
| Muzaffar Hussain Shah | March 6, 1992 | July 19, 1993 | Islami Jamhoori Ittehad |
| Syed Ali Madad Shah (caretaker) | July 19, 1993 | October 21, 1993 | |
| Syed Abdullah Shah | October 21, 1993 | November 6, 1996 | Pakistan Peoples Party |
| Mumtaz Bhutto (2nd time; caretaker) | November 7, 1996 | February 22, 1997 | Sindh National Front |
| Liaquat Ali Jatoi | February 22, 1997 | October 30, 1998 | Pakistan Muslim League (N) |
| Governor's rule-No Chief Minister | October 30, 1998 | December 17, 2002 | |
| Ali Mohammad Mahar | December 17, 2002 | June 9, 2004 | Pakistan Muslim League (Q) |
| Arbab Ghulam Rahim | June 9, 2004 | November 19, 2007 | Pakistan Muslim League (Q) |
| Abdul Qadir Halepoto (caretaker) | November 19, 2007 | April 6, 2008 | |
| Qaim Ali Shah (2nd time) | April 6, 2008 | Incumbent | Pakistan Peoples Party |